View Item 
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UU Student Theses RepositoryBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

        Virtual screening for non-carbohydrate inhibitors for cholera toxin B

        Thumbnail
        View/Open
        Damian Vingerhoets eindverslag minor research final edit.pdf (2.583Mb)
        Publication date
        2024
        Author
        Vingerhoets, Damian
        Metadata
        Show full item record
        Summary
        Multiple virtual screening methods were used to find non-carbohydrate ligands for cholera toxin B. Cholera toxin B is the binding component of the cholera toxin, which causes the cholera disease. To combat this cell-binding and thereby blocking the disease causing toxin A from entering cells, inhibitors are made. These inhibitors are however based on relatively complex carbohydrates. Carbohydrates have pharmacokinetic properties which makes them unsuitable and rather complex for drug use. Therefore we screened a large database of molecules using structure based screening and similarity screening techniques to find non-carbohydrate ligand candidates.
        URI
        https://studenttheses.uu.nl/handle/20.500.12932/47555
        Collections
        • Theses
        Utrecht university logo