UU Theses Repository
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Stages and Phases in Development, Evaluation and Implementation of Clinical Prediction Models: A Systematic Literature Review and Content Analysis
(2024)Abstract Background: In an era of “big data”, medical information is increasingly accessible for use in patient care. Recently numerous prediction models have been developed using the association of multiple known clinical ... -
De toepassing van de geografische werkwijzen in het profielwerkstuk aardrijkskunde
(2024)“Hoe nuttig is het profielwerkstuk?” Dit is een vraag die vaak gesteld wordt, want leert de leerling nou wel of niet iets? Er is nog weinig onderzoek gedaan naar de vaardigheden die door leerlingen worden toegepast in het ... -
The effect of claw trimming on the severity and occurrence of lameness in goats
(2024)Claw disorders are a significant welfare and health issue in dairy goats, often leading to lameness, reduced performance, and economic losses. This study investigates the effect of a single claw trimming event on the ... -
gplasCC: a robust plasmid reconstruction tool using short-read data from any bacterial species
(2024)Plasmids play a pivotal role in the spread of antibiotic resistance genes (ARGs). Accurately reconstructing plasmids often requires long-read sequencing, which is more expensive and still more error-prone than short-read ... -
Personalized Gene Therapy for Fanconi Anemia: Precision Prime Editing to Target Hematopoietic Stem Cells
(2024)Fanconi Anemia (FA) is a severe genetic disease that often results in progressive loss of bone marrow function. The FANCA gene is one of the 23 genes that can be mutated in FA patients and is mutated in more than 60% of ... -
De koepel centraal: de bouwgeschiedenis van de Sint-Aloysiuskerk en de eerste stappen van H.W. Valk als zelfstandig kerkarchitect
(2024)In dit onderzoek wordt de Sint-Aloysiuskerk te Utrecht van architect H.W. Valk onderzocht. Dit rooms-katholieke kerkgebouw, met centrale plattegrond en rijzige koepel, vertoont invloeden van historische architectuur en is ... -
RISK OF DEATH DUE TO PRE-EXISTING CARDIOVASCULAR DISEASE RISK IN SOUTHEAST ASIAN WOMEN WITH BREAST CANCER
(2024)Objective: Cardiovascular disease (CVD) is an important cause of death in women with breast cancer, especially in those with pre-existing CVD risk factors. The aim of this study was to examine if pre-existing CVD risk at ... -
Step up your game: A research on two/multi-step summarisation of long, regulatory documents
(2024)Automatic Text Summarization (ATS) is the process of automatically summarizing a text. Advancements in neural models in Natural Language Processing (NLP) have significantly enhanced summarization capabilities, making it a ... -
Spin implementation of the bosonic Kitaev chain.
(2024)In this project, we develop a concrete theoretical proposal for the bosonic Kitaev chain that is based on interacting spin systems/nanomagnets. We then study the non-linear dynamics of the model, the chiral spin transport ... -
Finding the maximal independent sets with dynamical systems
(2024)Finding maximal independent sets is a classical problem in graph theory. In this thesis, we extend the related concepts in graph theory to k-uniform hypergraphs, attempting to find the maximal independent sets in hypergraphs ... -
Verbs or Nouns? The Headedness and Malleability of Mandarin Disyllabic Compounds
(2024)This thesis explores the noun-verb categories of disyllabic compounds in Mandarin under the theoretical frameworks of Distributed Morphology (Halle and Marantz 1993, Harley and Noyer 1999) and Exo-skeletal Model (Borer ... -
Towards Cruelty-free Botulinum Toxin Testing: Current Situation and Roadblocks
(2024)Botulinum neurotoxin (BoNT), more commonly known as Botox, is a biological toxin produced by bacteria and is characterized by its paralytic effect on nerve cells. BoNT is used for medical applications such as muscle spasms ... -
Reconstructing NCBI SRA plasmids for global analysis of antimicrobial resistance genes
(2024)Antimicrobial resistance (AMR) is a critical global health threat, driven by bacteria evolving to withstand existing treatments. Addressing AMR requires understanding the spread of antimicrobial resistance genes (ARGs) ... -
The patient’s perspective: a review on epidermolysis bullosa patients’ needs as input towards harmonization of outcomes
(2024)Epidermolysis Bullosa (EB) comprises a heterogenous group of rare genetic skin disorders, characterized by blistering. EB is classified in four major types: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB), and ... -
Influence of Scientific Advice on Marketing Authorisation and post-authorisation withdrawal of ATMPs
(2024)Background: Regulators from the European Medicines Agency (EMA) provide comprehensive guidelines and expert guidance before Market Authorisation Application (MAA) to enhance the chance of Market Authorisation (MA). The ... -
Translabyrinthine approach and the sigmoid sinus: a quantitative 3D analysis of exposure in cadaveric specimens.
(2024)Introduction: Perioperative sigmoid sinus compression and sinus injury might be associated with various post-operative complication (e.g., CFS leakage, headache, intracranial hypertension, cerebellar infarct). This study ... -
Poor outcome in ICU patients acutely intoxicated by street drugs
(2024)This study looked at the occurrence of “poor outcome (death, complications or ICU stay > 72 hours)” as a primary outcome. The street drugs are compared to non-street drugs and there was a comparison between the different ... -
Pt Nanoparticle Facets Characterised by CO Adsorption with Infrared Spectroscopy
(2024)Platinum nanoparticles (Pt NPs) are used extensively as catalysts in numerous catalytic reactions. The shape and size of these nanoparticles can affect the activity and selectivity of these reactions. It is, therefore, ... -
Pricing and reimbursement of Tumour-agnostic Therapies
(2024)Abstract Background: Larotrectinib and entrectinib are tumour-agnostic therapies that received marketing authorization from the European Medicines Agency (EMA) in 2019 and 2020. In the Netherlands, both therapies are ... -
Beyond Remission: An In-Depth Exploration of Recovery Needs, Gaps, and Obstacles Faced by Working-Age Breast Cancer Survivors – A Qualitative Study
(2024)Background: Breast cancer (BC) is the most prevalent cancer in women worldwide, with approximately 1 in 7 women receiving a diagnosis during their lifetime. The survival rate of BC has increased from 47,600 to 75,000 in ...