Genetic analysis reveals Association of LGR4 Mutation with Osteosarcoma in the Irish Wolfhound

Abstract

The aim of this study was to develop more insight into the genetic background of osteosarcoma in the Irish Wolfhound by identifying relevant genetic factors. To accomplish this aim 170.000 SNPs went for analysis and after identifying promising SNPs multiple PCR’s testes were ran to check for variations between case and control groups and correlations with osteosarcoma. The results showed a significant SNP housing the LGR4 gene. The LGR4 gene displayed multiple variations.

(see report)