Genetic analysis reveals Association of LGR4 Mutation with Osteosarcoma in the Irish Wolfhound

dc.rights.license	CC-BY-NC-ND
dc.contributor	P.A.J. Leegwater
dc.contributor.advisor	Leegwater, Peter
dc.contributor.author	Visser, Nynke
dc.date.accessioned	2024-05-29T23:02:42Z
dc.date.available	2024-05-29T23:02:42Z
dc.date.issued	2024
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/46448
dc.description.abstract	The aim of this study was to develop more insight into the genetic background of osteosarcoma in the Irish Wolfhound by identifying relevant genetic factors. To accomplish this aim 170.000 SNPs went for analysis and after identifying promising SNPs multiple PCR’s testes were ran to check for variations between case and control groups and correlations with osteosarcoma. The results showed a significant SNP housing the LGR4 gene. The LGR4 gene displayed multiple variations. (see report)
dc.description.sponsorship	Utrecht University
dc.language.iso	EN
dc.subject	Identifying genetisc factors of osteosarcoma in the Irish Wolfhound
dc.title	Genetic analysis reveals Association of LGR4 Mutation with Osteosarcoma in the Irish Wolfhound
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	Osteosarcoma, genetic, dog, canine, Irish Wolfhound
dc.subject.courseuu	Geneeskunde van gezelschapsdieren
dc.thesis.id	31135