View Item 
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UU Student Theses RepositoryBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

        On another level: the role of ubiquitination in endothelial inflammation

        Thumbnail
        View/Open
        Report.pdf (2.101Mb)
        Publication date
        2022
        Author
        Jager, Shelley
        Metadata
        Show full item record
        Summary
        Endothelial cells form the lining of the bloodvessel. They form the fysical barrier between the blood and tissue, they provide nutrient exchange and prevent coagulation. Upon inflammation, endothelial cells are activated, resulting in a variety of molecular and celullar responses. Previously, the endothelial response to IFN and TNF has been investigated and it was found that both lead to a unique response. Additionally, costimulation of both cytokines seemed to enhance this response synergistically. Here, we examine the role of ubiquitin in TNF induces endothelial inflammation. We describe our optimized protocol show upregulated ubiquitin sites that are in consensus with previous studies in other cell types.
        URI
        https://studenttheses.uu.nl/handle/20.500.12932/43269
        Collections
        • Theses
        Utrecht university logo