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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorAltelaar, A.F.M.
dc.contributor.authorJager, Shelley
dc.date.accessioned2022-12-01T01:01:49Z
dc.date.available2022-12-01T01:01:49Z
dc.date.issued2022
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/43269
dc.description.abstractEndothelial cells form the lining of the bloodvessel. They form the fysical barrier between the blood and tissue, they provide nutrient exchange and prevent coagulation. Upon inflammation, endothelial cells are activated, resulting in a variety of molecular and celullar responses. Previously, the endothelial response to IFN and TNF has been investigated and it was found that both lead to a unique response. Additionally, costimulation of both cytokines seemed to enhance this response synergistically. Here, we examine the role of ubiquitin in TNF induces endothelial inflammation. We describe our optimized protocol show upregulated ubiquitin sites that are in consensus with previous studies in other cell types.
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectUbiquitination in endothelial inflammation
dc.titleOn another level: the role of ubiquitination in endothelial inflammation
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsProteomics; Endothelial inflammation; ubiquitination; ubiquitinomics
dc.subject.courseuuDrug Innovation
dc.thesis.id12059


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