View Item 
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UU Student Theses RepositoryBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

        Opportunities for Single-Cell Approaches in Cancer Epigenomics

        Thumbnail
        View/Open
        WritingAssignment_SingleCellCancerEpigenomicsReview_MartaMorenoGonzalez.pdf (1.225Mb)
        Publication date
        2022
        Author
        Moreno Gonzalez, Marta
        Metadata
        Show full item record
        Summary
        Epigenetic alterations are reversible modifications that alter the way gene expression is regulated without changing the underlying DNA sequence. They play a key role in both healthy development, as well as in diseases like cancer. During the last decade, we have seen the development of novel methods to study the different layers of the epigenome (DNA methylation, histone modifications, non-coding RNAs, chromatin accessibility, and chromatin architecture) at a single-cell level. These methods provide a unique opportunity to study the impact of epigenetics in the development of intra-tumor heterogeneity and its effects on cancer development, drug resistance, and progression towards metastasis. In this review, we provide an overview of how epigenetic modifications regulate gene expression and the currently existing single-cell epigenomic methods, as well as an explanation on how these methods can be used to expand our current knowledge on the role of epigenetics in cancer.
        URI
        https://studenttheses.uu.nl/handle/20.500.12932/42816
        Collections
        • Theses
        Utrecht university logo