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        Modeling resistance to vemurafenib using integrative approaches: pitfalls and opportunities

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        Lambo, S.
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        Summary
        Drug resistance against targeted inhibitors is a complex problem that prevents efficient treatment of many tumors. Drug resistance can occur on multiple levels, requiring the acquisition and integration of system-wide data. We review the pitfalls of data integration across different layers of biology together with possible approaches to integrate the data. Additionally, we propose a model that enables the identification of mechanisms that underlie drug resistance through the integration of different layers of biological data.
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        https://studenttheses.uu.nl/handle/20.500.12932/29714
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