Theses: Recent submissions
Now showing items 4301-4320 of 45930
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Agreement Between EMA and HTA Organizations About Whether Alternative Treatments Exist and Associations with Relative Effectiveness Assessments
(2024)In Europe, the European Medicines Agency (EMA) and national and regional health technology assessment (HTA) organizations discuss alternative treatments when evaluating a drug. The EMA recommends about marketing authorization ... -
The Effect of Cell Cycle Progression and a Nuclear Localization Signal on CRISPR/Cas9 Gene Correction
(2024)The CRISPR/Cas9 system enables site-specific genome-editing which predominantly occurs via Non-Homologous End Joining (NHEJ), a relatively error-prone pathway. Another pathway is gene correction via Homology Directed Repair ... -
Identification of the Expression Patterns of Fatty Acid Oxidation Genes in a Heterogenic Cardiomyopathy Patient Cohort
(2024)Cardiomyopathy is one of the major causes of heart failure that affects approximately 26 million patients worldwide. In a healthy situation, the heart depends on fatty acid oxidation (FAO) to maintain its energy demand. ... -
Cyber Threats of Shadow IT in Dutch Higher Education and Research
(2024)Usage of IT (information technology) in higher education institutions (HEIs) is influenced by the sector’s diverse user needs and culture of academic freedom, openness, and innovation. Besides the IT managed by the ... -
Evolution of division of labor in self-organizing spatially structured groups
(2024)In an evolutionary transition in individuality, a collection of individuals organizes into a group that becomes an individual in its own right. Division of labor among individuals in a group is frequently used as an indicator ... -
Adherence, discontinuation and withdrawal symptoms for low-dose mirtazapine and amitriptyline in patients with insomnia disorder
(2024)Laaggedoseerde mirtazapine (7.5-15 mg) en amitriptyline (10-20 mg) worden vaak op grote schaal off-label voorgeschreven aan patiënten met insomnie. Als onderdeel van de Drug REdiscovery: low-dose Amitriptyline and Mirtazapine ... -
Side effects of low-dose mirtazapine and amitriptyline in patients with insomnia: a randomized, double-blind, placebocontrolled trial
(2024)This study reveals the frequency, nature, and severity of the self-reported side effects of a low-dose amitriptyline and mirtazapine in comparison to placebo. It is assumed that in the future these results in addition to ... -
Increasing Smartphone Screen Time Awareness using an Ambient Information System
(2024)Smartphones have become ubiquitous in modern life, but the amount of time spent using them can be a source of conflict for many users. Digital-Self Control Tools (DSCT) are apps that aim to assist users in tracking and ... -
A Systematic Review of the Effect of Macrolide Use in Food Producing Animals and its Impact on Rates of Human Carriage and Disease of Macrolide-Resistant Bacteria
(2024)Layman's Summary: Campylobacteriosis is a common illness caused by Campylobacter spp.. which causes a global loss in nearly the in nearly 33 million healthy human life years globally annually (the World Health Organization ... -
Exploring and genotyping APOE allele variants in RNA sequencing data for the study of amyotrophic lateral sclerosis
(2024)Amyotrophic lateral sclerosis (ALS) is the third most occurring neurodegenerative disease in humans and is defined by its heterogeneous clinical presentation. Over the years, many genes related to ALS were discovered by ... -
Play behavior: Testing a novel tool to study play in children and impact of acute corticosterone on play behavior
(2024)Play is important for the development of non-human mammals and humans. Children that are in development benefit from play behavior to learn about social competence, solve complex problems and train their cognitive flexibility. ... -
The effects of water on limb and upper-body kinematics in horses walking and trotting in a water track.
(2024)Rehabilitation after a musculoskeletal injury has become an essential part of veterinary care. Various forms of exercise in water have been described as an effective medium to improve function while preventing further ... -
A Closer Look at the Surface. Structural biology of prokaryotic cell surface molecules.
(2024)Most prokaryotes are encapsulated by a para-crystalline (glyco)protein array termed surface layer or S-layer, which mediates the interaction between the cell and its environment. Despite wide variation between prokaryotes ... -
Predicting wellbeing in Latin America with use of classification methods
(2024)Individual life satisfaction has implications that go beyond one’s personal life having potential to influence social and economic indicators as well. Its significance has made it a field of study in recent decades. ... -
The epidemiology of traumatic open globe injuries in children: an overview of the last 21-years in a tertiary hospital in the Netherlands
(2024)Introduction: Pediatric open globe injuries are an important cause of non-congenital monocular visual acuity loss in children. In young children, who are still in their visual development, amblyopia is of great concern. ... -
"Standardization of mRNA transfection of Natural Killer cells for immune therapy purposes. "
(2024)Human natural killer (NK) cells have received much interest due to significant progress in understanding their function and some promising findings in tumor therapy. NK cells are cytotoxic lymphocytes that have the ability ...