Theses: Recent submissions
Now showing items 4321-4340 of 45930
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Investigating the effect of risky play on cognitive performance and anxiety in rats
(2024)Risk-taking is an important component of play, through which children learn risk assessment, test and develop motor skills, and learn how to master challenging situations. Additionally, it has been suggested that exposure ... -
BIOSECURITY MEASURES TO REDUCE HEPATITIS E VIRUS TRANSMISSION WITHIN PIG FARMS
(2024)Hepatitis E virus (HEV) can infect humans and cause inflammation of the liver. For people living in industrialized countries, pigs are the main source of human infection. Pigs that become infected do not fall ill, but they ... -
Docetaxel for castrate-resistant prostate cancer: the effect of hepatic impairment at the start of therapy on the incidence of adverse events.
(2024)Introduction Metastasized castration-resistant prostate cancer (mCRPC) is a common type of cancer in European and United States men. Docetaxel (75 mg/m2 as a 60-minute infusion once every 21 days (Q3W)) is a potential ... -
The Role of Service Dogs in Families of Veterans Diagnosed with PTSD
(2024)Social support and family relationships are important predictors of post-traumatic stress disorder (PTSD) symptom severity. Besides, the partner and children of veterans are also negatively affected by the PTSD. Not all ... -
A Comparison of Methods of MRSA Detection in Dutch Pig Farms
(2024)Layman’s summary: Methicillin Resistant Staphylococcus aureus (MRSA) is a S. aureus bacterium which is resistant to most -lactam antibiotics. Antibiotics in this class make up a majority of the antibiotics prescribed to ... -
Immunomodulatory antibacterial surfaces to prevent implant-related infection
(2024)As orthopedic surgeries become more frequent, so do implant-associated infections. Typically, the major risk of infection is due to bacterial colonization, this jeopardizes the integration of the implant ultimately leading ... -
The role of ASD-linked histone lysine demethylase KDM5B in cortical development
(2024)Epigenetic mechanisms are of great importance in the temporal and spatial regulation of the formation of the cortex. Disruption can result in neurodevelopmental disorders, such as autism spectrum disorder (ASD). Multiple ... -
Follow-Up of Specific Obligations Required for Conditionally Authorized Anticancer Medicinal Products by the European Medicines Agency in 2006-2021: An In-depth Analysis
(2023)Background: The European Medicines Agency (EMA) has implemented a regulatory pathway for the conditional marketing authorization (CMA) of medicinal products. This pathway aims to facilitate timely patient access to treatments ... -
Impact Of Country On Adverse Outcome In Acutely Intoxicated Patients In ICU: A Generalized Linear Mixed Models Analysis
(2023)Our study aimed to investigate poor outcomes among ICU patients with acute poisoning, with a specific focus on discerning international variations. Additionally, we assessed the efficacy of Generalized Linear Mixed Models ... -
Exploring user interactions with Generative AI for Product Design
(2023)This project aims to investigate the potential of Generative AI for product design by exploring the application of a prompt-to-image generative AI tool(which is based on the stable diffusion model) in generating new products ... -
Climate response of abrupt and steady stratospheric aerosol injection
(2023)As the consequences of climate change become more evident, efforts are being made to find ways to mitigate these effects. A promising temporary solution is Stratospheric Aerosol Injection (SAI), which is based on reflecting ... -
A study on mesoscale eddies in the Irminger Sea and Iceland Basin using high resolution mooring data and satellite altimetry
(2023)The Irminger Sea and Iceland Basin are the main regions of deep water formation which feed the lower limb of the Atlantic Meridional Overturning Circulation (AMOC). This deep water formation occurs due to deep convection ... -
A molecular and functional dissection of the GABAergic neuronal diversity in the ventral tegmental area
(2023)The ventral tegmental area (VTA) is a region in the brain that is involved in various behaviours and disorders, such as addiction. In the brain, different classes of neurons exist. These neurons are connected to each other ... -
Single cell RNA sequencing analysis of GFAP alternative splice isoforms in glioblastoma
(2023)Glioblastoma multiforme is a very aggressive brain tumor with extremely poor patient prognosis. Clinical treatment fails to fully treat glioblastoma due to its intratumoral heterogeneity and population of quiescent stem ... -
Fabrication of Vascularized Model for Bone Marrow Engineering
(2023)Currently the majority of our understanding of these niche-specific phenomena have been obtained from small animal and two dimensional models which have a limited spatiotemporal resolution and do not always accurately ... -
The underlying evidence for Advanced Therapy Medicinal Products
(2023)Abstract Background: Advanced Therapy Medicinal Products (ATMPs) are novel medicines that often offer new opportunities to treat conditions with a high unmet medical need. To allow for early authorisation and aiming for ...