Olfactory Bulbectomized Rat, a model for what?
Hebieshy, J.F. El
MetadataShow full item record
The olfactory bulbectomized rat has been used primarily as an animal model for the detection of anti- depressive properties of new chemical entities and their assessment against the currently available anti- depressants. This is mainly due to the fact that the chronic efficacy of anti-depressants and not the acute efficacy is detectable using the model which resembles the efficacy of such drugs in humans. This review covers the chronological process that led to this use of this animal model, revises the logical reasons that justify that use and suggests other diseases the OBX rat can be used as a model for, such as certain neurodegenerative disorders and traumatic brain injury. A special consideration is also included for the “golden hour” meaning the chemical changes in the brain which occur in the first hour after the initial impact of traumatic brain injury, during which medical intervention has the highest potential of decreasing the permanent damage. If used as soon as the surgery is complete, the OBX rat could be evaluated as a model for neuroprotective drugs.