dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | hendriksen, Hendrik | |
dc.contributor.author | Hebieshy, J.F. El | |
dc.date.accessioned | 2014-07-28T17:00:56Z | |
dc.date.available | 2014-07-28T17:00:56Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/17244 | |
dc.description.abstract | The olfactory bulbectomized rat has been used primarily as an animal model for the detection of anti-
depressive properties of new chemical entities and their assessment against the currently available anti-
depressants. This is mainly due to the fact that the chronic efficacy of anti-depressants and not the
acute efficacy is detectable using the model which resembles the efficacy of such drugs in humans. This
review covers the chronological process that led to this use of this animal model, revises the logical
reasons that justify that use and suggests other diseases the OBX rat can be used as a model for, such as
certain neurodegenerative disorders and traumatic brain injury. A special consideration is also included
for the “golden hour” meaning the chemical changes in the brain which occur in the first hour after the
initial impact of traumatic brain injury, during which medical intervention has the highest potential of
decreasing the permanent damage. If used as soon as the surgery is complete, the OBX rat could be
evaluated as a model for neuroprotective drugs. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 946881 | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.title | Olfactory Bulbectomized Rat, a model for what? | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | Olfactpry bulbectomized rat, depression, traumatic brain injury, | |
dc.subject.courseuu | Drug Innovation | |