BioConductor: Microarray versus Next-Generation Sequencing toolsets
Summary
Both microarray and next generation
sequencing platforms generate copious
amounts of data for each experiment.
Thus, computational tools are required to
handle and process such experiments.
For microarray analysis, many open-source
R packages have been developed, most of
which are available through the BioConduc-
tor project. With certain microarray plat-
forms, it is now possible to perform the entire
analysis chain using only BioConductor tools.
A comprehensive next-generation sequencing
toolchain in pure R/BioConductor has until
so far not been possible. Next-generation
sequencing analysis still requires the use of
disparate tools on disparate platforms: only
some of them in R.
This literature review reviewed the existing
BioConductor toolsets for both approaches,
and highlights key differences and similari-
ties.