Early predictors for hypertensive disorders of pregnancy in developing countries

Abstract

Hypertensive disorders of pregnancy are still one of the greatest maternal health problems worldwide. These disorders constitute of pre-existing hypertension and gestational hypertension, which then can progress into preeclampsia, eclampsia, and HELLP-syndrome. They contribute greatly to a large proportion of maternal and perinatal death, particularly in the developing countries. Early prediction, followed by proper management and timely treatment is proven to be effective in preventing complications and death related with these conditions. Various predictors such as maternal characteristics, Doppler ultrasound examinations, and biomarker analysis have been developed to accurately predict the women who are at risk. The need for reliable predictors is greatest in the developing countries, where health resources are limited. This thesis aims at giving an overview about the development of predictors for hypertensive disorders of pregnancy, which are suitable for application in developing countries. Various challenges in its implementation are also discussed.