Noncoding RNAs and Chromatin
Cordeiro Machado Rodrigues, R.J.
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During embryonic development organisms need to establish different cell types to carry out specific functions. Gene expression regulation through chromatin changes has more and more been found to play a major role in cellular differentiation. RNA has also been found to be a player in gene expression regulation through mechanisms like RNA interference. Recent studies show a great connection between RNA and chromatin, though this field is in a very early stage. Here I discuss these recent findings in the RNA and chromatin fields, focusing in noncoding RNAs. I will go through the mechanisms by which noncoding RNAs can regulate chromatin and gene expression. Through examples I will argue in favour that noncoding RNAs are important general players in chromatin remodelling and gene expression.