dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Ketting, R.F. | |
dc.contributor.author | Cordeiro Machado Rodrigues, R.J. | |
dc.date.accessioned | 2013-01-18T18:00:50Z | |
dc.date.available | 2013-01-18 | |
dc.date.available | 2013-01-18T18:00:50Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/12446 | |
dc.description.abstract | During embryonic development organisms need to establish different cell types to carry out specific functions. Gene expression regulation through chromatin changes has more and more been found to play a major role in cellular differentiation. RNA has also been found to be a player in gene expression regulation through mechanisms like RNA interference. Recent studies show a great connection between RNA and chromatin, though this field is in a very early stage. Here I discuss these recent findings in the RNA and chromatin fields, focusing in noncoding RNAs. I will go through the mechanisms by which noncoding RNAs can regulate chromatin and gene expression. Through examples I will argue in favour that noncoding RNAs are important general players in chromatin remodelling and gene expression. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 3057777 bytes | |
dc.format.mimetype | application/msword | |
dc.language.iso | en | |
dc.title | Noncoding RNAs and Chromatin | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | RNAi, RNAe, lncRNA, chromatin, silencing, noncoding, long noncoding, siRNA, piwi, piRNA, 21U, 22G, Swi6, epigenetic, RNA | |
dc.subject.courseuu | Cancer Genomics and Developmental Biology | |