UU Student Theses Repository: Recent submissions
Now showing items 1181-1200 of 45483
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Identifying endo-lysosomal alterations downstream of RAS mutations
(2025)The endo-lysosomal system is primarily responsible for vesicle transport and degradation but also plays a crucial role in nutrient sensing and metabolic signaling. As a result, the state of endo-lysosomal pathways significantly ... -
From Spatial Data Infrastructures To Spatial Knowledge Infrastructures – Evaluating the current state of concepts and cases
(2025)This study provides a first-time systematic review into the concept of a Spatial Knowledge Infrastructure (SKI) in comparison with the well-established Spatial Data Infrastructure (SDI) concept. Generalized, an SDI is a ... -
Decoding Large Scale High Density Neural Recordings in Non-Human-Primates using a Spiking Neural Network
(2025)To understand the complex processes underlying perception and action, it is necessary to understand the encoding mechanisms of information in the brain. Decoding, the mapping of brain responses back to a stimulus, is a ... -
A Proof-of-Concept Study on the Soil Ecosystem Effects of Holistic Planned Grazing for the Development of a Manual for Simple and Cost-Effective Soil Health Testing
(2025)With almost three quarters of all grazed land being degraded, there is a need for more biodiverse and resilient ecosystems in today’s grasslands. With the right management practices, grazing animals can play an important ... -
Decoding Neurodegeneration: Leveraging Machine Learning Approaches to Classify Single Cells and Identify Transcriptomic Features in Alzheimer’s Disease and ALS
(2025)Abstract Background: Neurodegenerative diseases like Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS) pose significant public health challenges due to their complex aetiologies involving genetic, environmental, ... -
Quantifying the historical surface mass balance of the Greenland ice sheet using both RACMO2.4p1 and in situ data, and its correlation with large scale atmospheric circulation
(2025)Increase in surface melting is the main contributor to Greenland Ice Sheet (GrIS) mass loss, therefore its quantification is extremely relevant in assessing the future rise of sea levels. However, direct measurements of ... -
Combining Normal Approximation Heuristics With Simulated Annealing For The Stochastic Job-Shop Scheduling Problem
(2025)This thesis addresses the Stochastic Job-Shop Scheduling Problem, incorporating uncertainty in the processing time. Efficiently creating robust schedules is computationally challenging due to the complex search space and ... -
A review of pollen-based quantitative vegetation reconstruction models
(2025)Quantitative vegetation reconstruction aims to provide information about past vegetation cover. One method is using pollen diagrams that are supposed to reflect the relative abundance of taxa in the surrounding vegetation. ... -
Clusterization and background estimation of a direct photon signal in pp collisions at √s=13.6 TeV in ALICE
(2025)This thesis presents a method to estimate the background contribution in a direct photon signal in proton-proton collisions at √s = 13.6 TeV in ALICE. This work serves as an initial step towards a comprehensive jet quenching ... -
Association patient characteristics on fludarabine exposure in patients with hematopoietic allogenic stem cell transplantation
(2025)ABSTRACT Background Hematopoietic allogenic stem cell transplantation provides a potential curative treatment for patients suffering from malignant or non-malignant diseases. Conditioning by fludarabine and busulfan forms ... -
Medication Use and Adverse Maternal, Pregnancy and Neonatal Outcomes among Pregnant Women with COVID-19: A Prospective Individual Patient Data Meta-analysis in Europe and North America
(2025)Pregnant women are a vulnerable group during the COVID-19 pandemic, yet they have been largely left out of important studies on how to treat and prevent the virus. This leaves big gaps in our knowledge about how different ... -
SBRT in oligometastatic disease of colorectal cancer
(2025)INTRODUCTION.Throughout the recent years, stereotactic body radiotherapy (SBRT) has emerged as an effective, local therapy for treating limited (oligo) metastatic disease. This study presents characteristics and clinical ... -
Surface circulation and marine debris: exploring the impact of northwestern African upwelling on offshore transport
(2025)Amidst the global challenge of plastic pollution, the marine environment surrounding the Canary Islands is not immune to this pressing issue. Besides, the northwestern African upwelling system is an ideal environment for ... -
The Potential Applications and Limitations of in vitro Models for Studying the Gut-kidney Axis in Chronic Kidney Disea
(2025)Chronic kidney disease is a detrimental condition characterized by the irreversible and progressive loss of renal function. CKD can be initiated by various triggers including but not limited to abnormal kidney development, ... -
Prompt repairs and prompt patterns: Improving prompt engineering for automated medical reporting
(2025)In Netherlands, doctor spend more than 40% of their workload in writing medical report which caused too much administrative burden. Currently, Caare2Report found out a sulution which is recording what the doctor and patient ...