Modelling the Dynamics of Epithelial Tissue
Rele, T.R. Ter
MetadataShow full item record
Jamming behaviour has been observed in epithelial tissue. We tried to get more insight into jamming behaviour in monolayers of cells through numerical modelling. In our simulation epithelial cells were modelled as soft-potential spheres and soft-potential dumbbells. Oscillations in cell length and size were used to study the eﬀect of deformation of cells on the collective dynamics of epithelial tissue. Jamming was observed in systems of passive disks, but jamming disappeared as cell oscillations were introduced. All simulated systems with dumbbells were linearly diﬀusive. Adding oscillations to the dumbbells increased the diﬀusivity of the system, especially at higher densities. The model of oscillating dumbbells used in this thesis was successful in showing the eﬀect of oscillations on the dynamics of diﬀusive systems. However, it did not succeed in simulating jamming. For future research it will be necessary to look further into creating a diﬀerent model of deforming epithelial cells if we want to study jamming behaviour.