View Item 
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UU Student Theses RepositoryBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

        How T-cells influence microglia to form a feedback loop that accelerates disease progression in Parkinson’s disease

        Thumbnail
        View/Open
        0424625_thesis.pdf (274.9Kb)
        Publication date
        2011
        Author
        Loeff, F.C.
        Metadata
        Show full item record
        Summary
        Parkinson’s disease (PD) is a movement disorder characterized by extensive degeneration of dopaminergic neurons in the nigrostriatal pathway. Although several gene mutations and toxins are correlated with inherited and induced forms of PD, causes of initiation of sporadic PD remains debated. In this thesis I will give a general introduction of PD and an overview of the literature on PD initiation. However most importantly, I will give an overview of the recent literature discussing the involvement of the adaptive immune system on the progression of PD. Here we will specifically focus on the involvement of T-cells in the pathogenesis of PD. Also, possibilities to influence PD by inducing differential T-cell subtypes, such as Thelper1 cells, Thelper2 cells, and Tregulatory cells, will be discussed.
        URI
        https://studenttheses.uu.nl/handle/20.500.12932/6484
        Collections
        • Theses
        Utrecht university logo