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        Non-canonical peptides presented on MHC molecules as possible biomarkers for (immune)therapies.

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        Major Research Project Final Report - Manuel Ayllon Gavilan.pdf (1.947Mb)
        Publication date
        2025
        Author
        Ayllón Gavilán, Manu
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        Summary
        Recent advances in neoantigen research have accelerated the development and approval of tumor (immune)therapies, particularly antibody-based treatments for solid tumors. Neoantigens, arising from tumor-specific changes such as genomic mutations, dysregulated RNA splicing, and post-translational modifications, are newly formed antigens in tumor cells. The identification and prediction of these neoantigens have been facilitated by advancements in next-generation sequencing (NGS) and bioinformatic
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        https://studenttheses.uu.nl/handle/20.500.12932/49077
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