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        Heterogeneity of senescence cancer cells and their pleiotropic non-cell autonomous effects

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        Heterogeneity of senescence cancer cells and their pleiotropic non-cell autonomous effects__.pdf (479.3Kb)
        Publication date
        2024
        Author
        Athanasopoulou, Niovi
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        Summary
        Cellular senescence, a response to various stress signals, involves a stable exit from the cell cycle along with significant changes in cell function and physiology. Although many studies have focused on senescence in non-cancerous cells, it is evident that cancer cells can also enter a senescent state. Senescent cancer cells exhibit considerable variability due to both intrinsic and extrinsic factors. In this review, we explore the heterogenous autonomous and non-cell autonomous characteristics of senescent cancer cells and their diverse relationship to tumor progression. In addition, we discuss the potential and challenges of using senotherapies as novel anti-cancer treatments. By understanding the context-specific effects of senescent cancer cells, we may be able to harness their tumor-suppressive benefits while minimizing their harmful consequences, leading to new therapeutic strategies for cancer.
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        https://studenttheses.uu.nl/handle/20.500.12932/48029
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