Heterogeneity of senescence cancer cells and their pleiotropic non-cell autonomous effects
Summary
Cellular senescence, a response to various stress signals, involves a stable exit from the cell cycle
along with significant changes in cell function and physiology. Although many studies have
focused on senescence in non-cancerous cells, it is evident that cancer cells can also enter a
senescent state. Senescent cancer cells exhibit considerable variability due to both intrinsic and
extrinsic factors. In this review, we explore the heterogenous autonomous and non-cell
autonomous characteristics of senescent cancer cells and their diverse relationship to tumor
progression. In addition, we discuss the potential and challenges of using senotherapies as novel
anti-cancer treatments. By understanding the context-specific effects of senescent cancer cells,
we may be able to harness their tumor-suppressive benefits while minimizing their harmful
consequences, leading to new therapeutic strategies for cancer.