Using Whole Genome-Wide Genetic Information for Making Choices in Drug Therapy Use
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It is no secret that the genomic era is upon us. Through the wealth of data generated by the Human Genome Project, in conjunction with parallel advances in genomics, proteomics, bioinformatics and biotechnology, the personal genome has become readily accessible. It is currently being applied in pharmacogenomics, which utilizes the personal genome as a means to detect biological markers associated with drug outcomes in order to direct drug therapy. This paper addresses current applications of pharmacogenomics, including the anticipated benefits, its promise and the tools used for uncovering genetic markers and molecular diagnostics. Also, technological advances, genome-wide association studies, as well as limitations and potential ethical ramifications are further discussed.