The role of cell polarity in regulating the Salvador/Warts/Hippo tissue size control pathway
Espitia Pinzón, N.
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Currently, it is not known how cell polarity influences tissue size control during development and in the adult. Here we describe how polarity pathways and the Salvador/Warts/Hippo (SWH) pathway interact to control tissue size. We discuss several recent studies, which give important insights into possible molecular mechanisms underlying such an interaction. To set the stage to discuss this recent literature, we will first consider the cellular junctions, the regulators of apicobasal and planar cell polarity, and the components of the SWH pathway.