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        Keeping a Genomic Jungle in Check; How Eukaryotic Cells Regulate the Positive Feedback of Heterochromatin Expansion

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        Writing Assignment; Keeping a Genomic Jungle in Check; Bert Jan Korte.pdf (916.8Kb)
        Publication date
        2024
        Author
        Korte, Bert Jan
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        Summary
        Eukaryotic genomes contain many repetitive sequences that, without constant repression, can induce genomic instability via rogue transcription, recombination, and transposition. Repression of these sequences occurs through constitu- tive heterochromatin, a condensed phase consisting of H3K9me2/3-marked nucleosomes bound to DNA. Interestingly, whilst heterochromatin nucleation in sequence-dependent, its propagation is both sequence-independent and self-reinforced via positive-feedback loops. As the abnormal repression of genes can have large implications for cellular fitness, it is important that these mechanisms be spatiotemporally regulated. How this is mediated is, however, not fully known. In this review, we examine recent findings on the nucleation, spreading and regulation of constitutive heterochromatin. We then use this infor- mation to form models explaining the regulation of constitutive heterochromatin, to speculate on topics for future research.
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        https://studenttheses.uu.nl/handle/20.500.12932/46119
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