Factors associated with willingness to participate in scientific research among antidepressant users: a qualitative study

Abstract

ABSTRACT Background: Researchers report challenges to involve antidepressant users in their scientific research. Aim: To investigate factors associated with willingness to participate in scientific research among users of antidepressants. Methods: A qualitative study was conducted involving 267 reasons derived from enrollment data of ongoing studies regarding antidepressant usage, interviews with four research assistants, and a focus group discussion with four antidepressant users. Results: Nine themes were identified: fear, trusting relationship and recognition, taboo/stigma, societal responsibility, practical considerations, the impact of study design, recruiter competence, mental condition, and personal benefit. Discussion and Conclusion: This study uncovers ambivalence among antidepressant users regarding research participation. Fears include relapse and navigating life without medication, while motivation stems from reducing stigma and fostering open discussions. The willingness to participate is linked to the severity of depressive symptoms, with effective recruitment and trust in healthcare providers enhancing engagement.