View Item 
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UU Student Theses RepositoryBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

        The efficacy of five new attenuated mycobacterial strains compared to BCG as a vaccine against experimental challenge with Mycobacterium bovis in brushtail possums (Trichosurus vulpecula)

        Thumbnail
        View/Open
        Scriptie-met-bijlages.zip (3.787Mb)
        Publication date
        2010
        Author
        Das, E.J.
        Metadata
        Show full item record
        Summary
        Vaccinating wildlife against bovine tuberculosis (Tb), in countries with wildlife reservoirs of M. bovis, is thought to be the future solution to prevent livestock from getting re-infected. Five newly attenuated strains of mycobacteria have been developed to provide a possibly better vaccine than BCG against M. bovis in brushtail possums in New Zealand. Strain 2 turned out to give a significantly better protectection against experimental infection with M. bovis in three out of nine measurements when being compared to the none-vaccinated control group. Strains 1 and 5 showed two out of nine; strain 3, 4 and BCG showed zero out of nine measurements of protection that were significantly different than the control group. The use of a new scoring system for the analysis of histological slides is evaluated. The scoring of both granuloma characteristics in the liver and acid fast organisms (AFOs) in the lung seems most promising for the use in future microscopical examinations of possums with Tb.
        URI
        https://studenttheses.uu.nl/handle/20.500.12932/4430
        Collections
        • Theses
        Utrecht university logo