Evaluation of the interspecific variations of BPA disposition in pigs and ewes
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The purpose of this study was to document the interspecific variability between species of the BPA pharmacokinetic parameters. BPA is a constituent of polycarbonate and epoxy resins largely used in the food industry. The estrogenic effects of BPA are demonstrated in numerous biological systems. This rapport documents the pharmacokinetic parameters of BPA in pigs and sheep. Our working hypothesis is that the quasi-total amount of BPA is metabolized to BPA-gluc and excreted in the urine. Our results showed that in pig and in sheep, BPA is rapidly metabolised and eliminated in urine. The non conjugated BPA was faster eliminated after IV administration in pig compared with sheep, with a plasma clearance of 125 ml/(kg.min) versus 35 ml/(kg.min). The half times of elimination in sheep and in pig were 1.25 and 0.67 h, respectively. In pigs and in sheep, around 40% of the total dose of BPA was excreted in the urine within 24 h after IV administration at the dose of 5 mg/kg. After oral administration of 100 mg/kg to pigs, the percentage of the total dose of BPA excreted in urine within 24 hours after administration was 55,4%. The oral bioavailability of non conjugated BPA in pig was very low.