A literature review of psilocybin administration in anxious mice. Highlighting the need for a more fundamental understanding of the cellular and molecular dynamics emerging from psychedelic experiences, for the treatment of anxiety

Abstract

This paper provides an overview of the current state of psychedelic research, with a particular focus on the potential role of psilocybin in the treatment of anxiety. While the effects of psilocybin are highly dependent on experimental protocols and procedures, animal biobehavioural research remains an indispensable tool for investigating the compound's therapeutic potential. Animal models can shed light on the mechanisms underlying the compound's effects on molecular, neurobiological, physiological, and behavioural processes, and inform the development of corresponding pharmacological interventions. However, the complexity of human psychology represents a major impediment to the translation of animal research findings into clinical practice. In addition to animal research, an integrative framework that combines psilocybin's acute effects with psychotherapeutic interventions is necessary for the treatment of anxiety. Finally, the paper emphasizes the importance of an ongoing dialogue between researchers, clinicians, and other stakeholders to ensure that scientific findings are effectively translated into clinical practice. Ultimately, the paper argues that with careful research and clinical practices, it may be possible to harness the power of natural compounds to alleviate anxiety and improve mental health outcomes.