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        Internal validity of a text mining algorithm to identify Adverse Drug Reactions in freetext entries from electronic health records of geriatrics and orthopedics patients

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        Dijck Loes van 6142036 FA-MA203.pdf (743.2Kb)
        Publication date
        2023
        Author
        Dijck, Loes van
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        Summary
        Background: Structured registration of adverse drug reactions (ADRs) in the electronic health record (EHR) is vital in preventing recurrence of ADRs, but in practice, ADRs are often saved as free-text only. Using a text mining tool could be useful in identifying these ADRs. Aim: To determine the internal validity of a previously developed ADR-identifying text mining algorithm at the geriatrics and orthopedics department at Catharina Hospital Eindhoven. Methods: One year of EHR data from 15 orthopedics patients and 6 geriatrics patients were manually reviewed for ADRs, creating a gold standard. MedDRA and SNOMED-CT terminology was used to identify symptoms and the Dutch G-standard database was used to identify offending medications. The same data was reviewed by the algorithm and its output was compared to the gold standard. Results: A total of 100 unique ADRs were identified in the gold standard, 20 of which were potentially serious. 14 ADRs were also found by the algorithm (true positives); 86 ADRs were marked as false negatives. The algorithm also returned 49 false positives. Overall, the algorithm reached a 22% PPV (positive predictive value), 14% sensitivity and an F-measure of 0.17. At the geriatrics department the PPV was 28%, as opposed to 15% at the orthopedics department. For serious ADRs, the algorithm reached an overall sensitivity of 20%. Conclusion: In this preliminary analysis, the algorithm did not meet our goals. This study needs to be finished in order to draw valid conclusions. Future research into this algorithm is required for further improvements and evaluation of its performance in different settings.
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        https://studenttheses.uu.nl/handle/20.500.12932/43528
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