Statistical shape modelling of osteoarthritic knee joint
Donno, Giulia De
MetadataShow full item record
Osteoarthritis (OA) is a degenerative joint disease caused by the deterioration of the cartilage within a joint. It is diagnosed in around 1 in 7 adults, and it is the leading cause of disability among elderly individuals. OA occurs frequently in the knee joint, causing pain, inflammation, swelling and, in its worse cases, reducing functionality. From imaging, it manifests as osteophytes, subchondral sclerosis, bone attrition, and asymmetric joint-space narrowing, leading to a unique shape of the bones. Currently no early biomarkers exist for this pathology, and pharmacological treatments only target symptoms, but not its cause. It has been proven that changes in bone shape can be found even more than one year prior to the onset of radiographic OA, and the joint space narrowing seems a good candidate to be used as biomarker. In order to properly visualize the joint space, however, imaging needs to be performed in a standing position. This is only possible in radiography (which provides 2D images) and not in 3D scan as Magnetic Resonance Imaging or Computed Tomography (which can provide an accurate 3D model of the joint). In this study, different ways to create statistical shape models that can provide accurate information on the anatomy of the knee joint under load are described, and currently registration involving 2D and 3D images seems to be the most suitable solution.
Showing items related by title, author, creator and subject.
A case-control study of bone density patterns in the metacarpophalangeal joint between non-racehorses and thoroughbred racehorses with and without fractures of the metacarpophalangeal joint Weenink, N.M. (2018)Reason for performing study The metacarpophalangeal joint carries high loads and is one of the most common sites of overload arthroses and joint failure. Racing seems to be a risk factor for fractures and fractures occur ...
MINIaturized JOINT structures and 3D-living microfluidics to study cartilage degenerative diseases MINI-JOINT Ginés Rodriguez, Núria (2023)In recent years, advances in fabrication techniques and 3D printing have allowed development in advanced in-vitro models as bioreactors. 3D bioprinting enables the manufacturing of complex and intricate architectures that ...
Join in! Joint Engagement of Toddlers With a Developmental Language Disorder During Daily ParentChild Interactions Hilhorst, I. (2021)This study is the first to examine joint engagement (JE) among parents and their toddlers with a developmental language disorder (DLD) during both storybook reading and play. JE are moments of shared interest between ...