dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Tanenbaum, Marvin | |
dc.contributor.author | Bergen, Louise van | |
dc.date.accessioned | 2022-06-04T00:00:42Z | |
dc.date.available | 2022-06-04T00:00:42Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/41608 | |
dc.description.abstract | Features encoded in the mRNA contribute substantially to the translation
efficiency of a transcript. After processing of the 5’ and 3’ end and export of the
mRNA to the cytoplasm, translation is initiated via a cap-dependent or capindependent mechanism. We describe how inhibition of global translation is
controlled by limiting translation initiation factors and how specific mRNAs
benefit from this to increase their expression during these conditions. We also
discuss how the mRNA codes for structural and regulatory elements which can
be recognised by trans acting factors to promote or inhibit translation. Finally,
we discuss how relatively new concepts as the epitranscriptome, codon
optimality and even the sequence of the nascent peptide influence translation
rates. | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | mRNA translation is the final step in the conversion of a gene to a protein. This process is heavily regulated by many factors. Features of the mRNA itself also control protein output. Here we describe which features a mRNA can have and how they contribute to translational control. | |
dc.title | mRNA features that guide
translational control | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.courseuu | Cancer, Stem Cells and Developmental Biology | |
dc.thesis.id | 4220 | |