| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Förster, Friedrich | |
| dc.contributor.author | Govers, Jolijn | |
| dc.date.accessioned | 2022-05-17T00:00:41Z | |
| dc.date.available | 2022-05-17T00:00:41Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/41569 | |
| dc.description.abstract | The resolution revolution has made cryo-electron microscopy an increasingly popular technique to study the structural biology of purified macromolecules and complexes. Extraction of these complexes can have a profound effect on their conformation since biomolecules are usually subject to modifications of and interactions with their native environment. Cryo-electron tomography (cryo-ET) presents a powerful approach to examine macromolecules in situ, enabling the high-resolution visualisation of the molecular organisation and localisation within the cell. | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | The resolution revolution has made cryo-electron microscopy an increasingly popular technique to study the structural biology of purified macromolecules and complexes. Extraction of these complexes can have a profound effect on their conformation since biomolecules are usually subject to modifications of and interactions with their native environment. Cryo-electron tomography (cryo-ET) presents a powerful approach to examine macromolecules in situ. | |
| dc.title | The potential and advances of cryo-ET: unravelling structural heterogeneity in situ | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.keywords | structural biology, cryo-electron microscopy, cryo-electron tomography | |
| dc.subject.courseuu | Molecular and Cellular Life Sciences | |
| dc.thesis.id | 3894 | |
