Theses: Recent submissions
Now showing items 1421-1440 of 46362
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The effect of enclosure structure on the positional behaviour of captive Bornean orangutans (Pongo pygmaeus)
(2025)Orangutans (Pongo) are the largest arboreal mammals and the only great apes that spend most of their life in the trees. Wild orangutans employ a great diversity of locomotion behaviours when traversing the canopy and are ... -
Attitudes about Progression Free Survival as a primary endpoint in clinical trials of anticancer drugs for advanced cancer, a systematic literature review
(2025)Abstract Background: Overall Survival (OS) has been traditionally the gold standard for the approval of anticancer treatments in advanced cancer. However, in light of the significant advances in treatments, clinical trials ... -
Comparison of the methods used to assess progression free survival (PFS) in clinical trials and in observational studies in Non-Small Cell Lung Cancer (NSCLC) patients treated with immunotherapy, a scoping review
(2025)Background Progression-Free Survival (PFS) is increasingly being used as the primary efficacy endpoint in registrational clinical trials in advanced cancer because it is available earlier than Overall Survival (OS) and it ... -
The costs of pharmaceutical 3D printing using Semi-solid extrusion 3D printing (SSE)A case study with hydrocortisone for adrenal insufficiency
(2025)The traditional pharmaceutical manufacturing of small molecule drugs in large quantities does not always address patient-specific requirements, thus necessitating personalized medicine. To take care of this, Semi-Solid ... -
Evaluating patient acceptability of digitalised PSA follow-up after prostate cancer treatment
(2025)Abstract Introduction Healthcare systems globally are facing increasing pressure, necessitating innovative solutions such as Telehealth. Digital follow-up methods, like the Automatic PSA Project, have the potential to ... -
Impact of saliva point-of-care testing on drug detection and clinical decision-making in the Emergency Department
(2025)Recent advancements in point of care tests (POCT) have introduced test kits capable of detecting drugs of abuse (DOA) in saliva, offering a potential solution to the challenges associated with urine or blood collection. ... -
RSV-specific ADCC in different age groups; the development of an ADCC killing assay with serum antibodies
(2025)RSV is a globally prevalent virus which is particularly problematic at an early age. Research speculates that young children have a different antibody-dependent cellular cytotoxicity (ADCC) capacity compared to adults ... -
Impact of Dutch annual grid fees on large-scale battery energy storage systems
(2025)This thesis examines the impact of the new Dutch annual grid fees policy proposed by TenneT on the annual net-profits of a typical 2-hour BESS in the Netherlands. BESS have the ability to adjust their total production ... -
The Effect of Human Behavior on the Spread of Bovine Tuberculosis in Wild and Domestic Populations in the UK
(2025)Bovine tuberculosis (bTB) is a zoonotic disease that is prevalent worldwide. The bacterium causing this disease (Mycobacterium bovis) frequently transmits from the wild host opulation it is endemic to, to domestic cattle. ... -
Nudge effectiveness under differing cognitive load
(2025)Drawing upon the dual-system framework, this study investigates the influence of cognitive load and environmental self-efficacy on the effectiveness of Type 1 and Type 2 nudges in promoting sustainable travel choices. It ... -
Person-Centred and Integrated Care: Understanding Barriers and Facilitators in the Dutch Context for the Care of Patients with Chronic Diseases and Multimorbidity
(2025)Person-Centred Integrated Care (PC-IC) has emerged as a promising approach to improve care for patients with multimorbidity. However, its implementation in primary care settings remains challenging. This study aimed to ... -
Spin-Dependent Off-Axis Holography: A Window into Spinor Bose-Einstein Condensates Dynamics
(2025)This thesis introduces a novel method for imaging spinor Bose-Einstein condensates (BEC). In particular, we focus on Sodium-23, a spin-1 composite boson. Traditional imaging techniques are based on destructive methods, ... -
Pharmacists' perspective on the potential introduction of pharmacist prescribing – a nationwide survey study
(2025)Background and objectives: Pharmacist prescribing legislation has been introduced in some countries to ensure quality and accessibility of healthcare. In many countries, like the Netherlands, pharmacist prescribing does ... -
Reasons for hospital admissions in low-risk syncope patients
(2025)Reasons for hospital admissions in low-risk syncope patients Background: Syncope is responsible for 1–3% of annual emergency department (ED) visits. The European Society of Cardiology (ESC) Syncope Guideline states that ... -
The initiators of the amiodarone-induced and lithium-induced hypothyroidism prescribing cascades: Recognizing it and how physicians communicate this
(2025)Background: not recognising prescribing cascades can be harmful to the patient. One of the potential complication factors in recognising a cascade can be incomplete or too little information transfer between physicians ... -
Drug repurposing imatinib in pulmonary arterial hypertension using PK/PD modeling
(2025)Goal: Pulmonary arterial hypertension (PAH) currently is an unmet clinical need with a high mortality rate. Published imatinib trials showed significant clinical response in PAH, but a relatively high toxicity. Hence the ... -
Photonic films from surfactant-coated cellulose nanocrystals in toluene for pressure and humidity sensing
(2025)Most inks use pigments that absorb light and consequently fade with excess sun exposure. Inspiration for a more sustainable, non-absorbing, alternative may be found in nature. Some organisms have developed structural ... -
Delirium Subphenotypes in the ICU: Comparing Effects on Cognition and Mortality
(2025)Introduction Delirium is a common and serious complication in intensive care unit (ICU) patients, associated with neuropsychiatric morbidity and mortality. Traditionally, delirium subtyping was based on observable psychomotor ... -
'Eenige opmerkingen over den zelfmoord': Emoties, motieven en zelfdoding in negentiende-eeuws Nederland (1809-1859)
(2025)In deze thesis is er onderzoek gedaan naar de emoties en motieven die verbonden waren aan zelfdoding in negentiende-eeuws Nederland (1809-1859). Voor het onderzoeken van de emoties en motieven, heb ik mij gewend tot een ...