Theses: Recent submissions
Now showing items 1-20 of 44272
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Activation of Glycolytic Enzymes in Red Blood Cells for Therapeutic Purposes
(2024)Background: Glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway and pivotal for maintaining redox balance in red blood cells (RBCs). Deficiency in G6PD can lead to hemolytic anemia, ... -
Guiding macrophages to resolution: insights into the transcriptional pro-resolving mechanisms
(2024)The inflammatory response is a tightly regulated process, which is essential for maintaining immune homeostasis. When this regulation is out of balance, persistence of the inflammatory response can lead to the development ... -
Using a Mouse Model to Study the Role of PBRM1 Loss in the Development of Clear Cell Renal Cell Carcinoma
(2024)A fundamental challenge when studying the evolution and origin of cancer is understanding the early events following oncogenic mutations. In the case of clear cell renal cell carcinoma (ccRCC), the truncal event is the ... -
Calibration of a Landscape Evolution Model in an Alpine Region: on the value of in-situ observations and transferability
(2024)Landscape evolution models (LEMs) are physics-based simulations that evaluate the influence of geomorphic processes on regional landscape development over longer time periods. These processes are represented in a simplified ... -
Predictive literature analysis and in vitro evaluation of Adenine base editors targeting the LMNA-Q493X mutation in murine fibroblasts
(2024)Cardiac laminopathies (LMNA-DCM) are an LMNA-associated subgroup of dilated cardiomyopathy (DCM), and one of the most common types of familial DCM. LMNA is a gene coding for A-type lamins, which are proteins integral to ... -
Various types of Microcredits lead to different success rates: a study in sub-Saharan Africa
(2024)This thesis investigates microcredit programs in Sub-Saharan Africa to discover their determinants of success. Investigating the historical trajectory of microfinance and existing microcredit models, this study identifies ... -
Geopolitical Risk and Bank Profitability: Evidence from European Countries (2013-2023)
(2024)This thesis delves into how geopolitical risk (GPR) affects the profits of banks in the Eurozone, an area known for its unity and political variety. The main question looks at how threats and actions on a geopolitical level ... -
Convergence or Divergence? Comparing the Evolution of SDG Implementation in EU and ASEAN Member States
(2024)This study investigates the longitudinal trajectory of Sustainable Development Goals (SDGs) implementation within the European Union (EU) and the Association of Southeast Asian Nations (ASEAN), exploring the potential for ... -
Octreotide and Delayed Bleeding after Endoscopic Papillectomy: a Propensity Score Matching Analysis
(2024)Background - Endoscopic papillectomy (EP) is widely used for managing ampullary lesions but carries risks of adverse events like delayed bleeding and pancreatitis. Octreotide has been proposed as a preventive measure for ... -
Building a Canine SNP Reference Database: Data Preprocessing and Quality Control Procedures
(2024)Canine genetics play a pivotal role in unraveling the genetic basis of inherited diseases in both dogs and humans. Single-nucleotide polymorphisms (SNPs) are a robust tool for genetic research and with the development of ... -
Exploring the Potential of Generative Machine Learning for Improving Collaboration and Decision-Making of Human Teams
(2024)This study explores the application of Large Language Models (LLM) in collaborative environments, emphasizing the integration of prompt engineering and the "Chain of Thought" method to mitigate hallucination in text ... -
The Role of the Built Environment in the Regenerative Transition
(2024)This research focuses on the environmental impact of cities, proposing a biomimetic approach for urban development. Cities can be redesigned to have a positive impact on the environment if their identity is challenged. For ... -
Waarden, wensen en behoeften van patiënten in de palliatieve zorg: een kwalitatief onderzoek naar de manier waarop zorgverleners in het ziekenhuis hier aandacht voor hebben in hun communicatie met de patiënt
(2024)Context: Het afstemmen van palliatieve zorg op de waarden, wensen en behoeften (WWB) van patiënten is belangrijk. Goede communicatie is het uitgangspunt, maar WWB komen niet altijd voldoende aan bod in de communicatie ... -
Using 3D protein models to uncover genetic risk in ALS
(2024)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by the involvement of rare genetic variants. Disease association of single rare variants can often not be tested. Therefore, ... -
Clinimetric properties of the CoCo-P: can we really distinguish cognitive functions?
(2024)Background: The Cognitive Complaints – Participation (CoCo-P) identifies cognitive complaints, specifically memory, attention, and executive functioning, as well as fatigue during participation. The CoCo-P seemed appropriate ... -
Designing Nature Positive Cities by applying Ecosystem-level Biomimicry
(2024)The impact of cities, such as biodiversity loss, climate change, and pollution, on local and far away natural ecosystems causes significant concerns within multiple sectors, prompting the need for sustainable solutions and ... -
Comparison of Culturing and Metabarcoding methods to describe the fungal microbiome of a Dutch forest soil along a gradient of CaCO3 treatments
(2024)Metabarcoding has gained popularity over traditional culturing methods as a more effective way to assess fungal biodiversity. Despite its potential, it still lacks the precision and taxonomic resolution of conventional ... -
Tailoring Cation Exchange in Nanomaterials
(2024)In this thesis, metal exchange in two different nanocrystalline systems is explored. Firstly, the partial In3+ for Cu+ cation exchange in a colloidal nanocrystal system of copper sulfide is studied. Excess trioctylphosphine ... -
Facial Recognition Technologies and Algorithmic Video Technologies for Mass Surveillance in Terms of The Right to Privacy: A Case Study if Paris Olympic Games 2024
(2024)This thesis explores the legal and privacy implications of using Facial Recognition Technologies (FRTs) and Algorithmic Video Surveillance Systems (AVSs) for mass surveillance during the Paris 2024 Olympic Games. The ... -
P3: Promoting Peatland Potential What are the effects of restoration measures on plant types in a degraded raised bog: The Fochteloërveen case study.
(2024)Anthropogenic impacts, including rising temperatures from fossil fuel emissions, widespread air and water pollution, and land use changes for farming and urbanization, have led to extensive destruction and degradation of ...