View Item 
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        •   Utrecht University Student Theses Repository Home
        • UU Theses Repository
        • Theses
        • View Item
        JavaScript is disabled for your browser. Some features of this site may not work without it.

        Browse

        All of UU Student Theses RepositoryBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

        Molecular composition and function of the kinetochore-microtubule interface in chromosome segregation.

        Thumbnail
        View/Open
        Master Thesis Charlotte Pennings eindversie.docx (694.0Kb)
        Publication date
        2014
        Author
        Pennings, C.
        Metadata
        Show full item record
        Summary
        Stable kinetochore-microtubule attachments are essential for equal division of chromosomes among daughter cells. To correctly separate chromosomes in mitosis, kinetochores must capture and bind spindle microtubules, stably attach to these dynamic structures, and release a microtubule when wrongly attached. In the past ten years, elaborate research has been done to explore and examine the key players that form the direct coupling between chromosomes and spindle microtubules. The KMN network, Dam1 complex in yeast, and Ska complex in mammalian cells are three main kinetochore complexes that compose the kinetochore-microtubule interface, and are required for proper chromosome segregation. Function and interplay of these complexes will be discussed in this review to gain more insight into how the dynamic process of chromosome segregation is regulated and to find gaps that need to be filled to fully understand the process.
        URI
        https://studenttheses.uu.nl/handle/20.500.12932/16575
        Collections
        • Theses
        Utrecht university logo