| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Reggiori, Fulvio | |
| dc.contributor.advisor | Rieter, Ester | |
| dc.contributor.author | Burgh, A.W. van der | |
| dc.date.accessioned | 2011-10-04T17:01:05Z | |
| dc.date.available | 2011-10-04 | |
| dc.date.available | 2011-10-04T17:01:05Z | |
| dc.date.issued | 2011 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/9251 | |
| dc.description.abstract | Autophagy is a cellular catabolic pathway and plays an important role in various diseases such as
cancer and neurodegeneration. In autophagy, there is the formation of an double-membrane vesicle
called the autophagosome. The only currently known protein responsible for membrane delivery to
the phagophore assembly site, where the autophagosome is formed, is Atg9. Atg9 cycles between its
reservoirs and the PAS, but the mechanisms of this cycling are poorly understood. Here, I discuss
what is currently known about the anterograde and retrograde of Atg9 trafficking in yeast and
compare it with trafficking in mammalian cells. Finally, I show a few experiments which provide data
on Atg18, one of the proteins involved in the retrograde transport of Atg9. | |
| dc.description.sponsorship | Utrecht University | |
| dc.format.extent | 1549274 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | |
| dc.title | Atg9 cycling: The molecular mechanisms of anterograde and retrograde Atg9 trafficking | |
| dc.type.content | Bachelor Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.keywords | Autophagy, Atg9, anterograde transport, retrograde transport | |
| dc.subject.courseuu | Biomedische wetenschappen | |
