dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Hoek, G. | |
dc.contributor.advisor | Lumens, M.E.G.L. | |
dc.contributor.author | Meesters, J.A.J. | |
dc.date.accessioned | 2011-07-14T17:01:57Z | |
dc.date.available | 2011-07-14 | |
dc.date.available | 2011-07-14T17:01:57Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/7395 | |
dc.description.abstract | Particulate matter is (PM) associated with various adverse health effects and mortality. The toxicological mechanism however and the role of particulate matter elemental composition in it is still unclear. The European Study of Cohorts for Air Pollution Effects (ESCAPE) has been launched in 2008 in order to quantify health impacts of air pollution and to reduce the uncertainty. One of these uncertainties is the role of particulate matter elemental composition on adverse health effects and mortality. The ESCAPE project cannot manage to evaluate all elements present in particulate matter. A selection of relevant elements needs to be made based on the current knowledge available. ESCAPE has chosen four different endpoints for their cohort studies: 1. Pregnancy and birth cohort studies; 2. Studies on respiratory diseases in adults; 3. Studies on cardiovascular disease in adults; 4. Studies on cancer incidence and mortality. The aim has been to find at least one recent scientific publication for each endpoint, but preferably two or three. Pregnancy and birth outcome, respiratory disease, cardiovascular disease, and mortality are the health effects which have been evaluated for associations with specific PM elements. Nickel and Vanadium have been significantly associated with al of these effects. Therefore it is advisable for ESCAPE to investigate the health impacts and uncertainties of elements Nickel and Vanadium in PM. Aluminum and Elemental Carbon show significant association for 3 health effects. Because these elements show significant association for the majority of the evaluated health effects, they seem to be appropriate for an ESCAPE study that does not focus on one endpoint. There is no element significantly associated to a certain health effect in more than one study, and show no significant associations to the other health effects. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 1489066 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.title | Review of PM elemental composition in association with oxidative stress, cancer incidence, cardiovascular and respiratory disease, health effects in pregnancy and birth outcome, and mortality | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | PM elemental composition, oxidative stress, cancer incidence, cardiovascular disease, respiratory disease, pregnancy and birth outcome, mortality | |
dc.subject.courseuu | Toxicology and Environmental Health | |