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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorVeen, A.A.B. van
dc.contributor.authorBouwmeester, R.A.M.
dc.date.accessioned2011-04-18T17:00:45Z
dc.date.available2011-04-18
dc.date.available2011-04-18T17:00:45Z
dc.date.issued2011
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/6885
dc.description.abstractThe human heart contracts approximately 75 times per minute under resting conditions. These contractions are mediated by fluctuations in cytosolic Ca2+ concentration. In heart failure the cardiomyocytes are not able to handle these Ca2+ signals properly. As a consequence the heart starts to remodel, a process initiated by altered gene transcription. The regulation of these processes is mediated by one and the same signalling ion, i.e. Ca2+. This review will discuss Ca2+ handling mechanisms ranging from cytosolic Ca2+ homeostasis and the regulation of gene expression to their role in heart failure.
dc.description.sponsorshipUtrecht University
dc.format.extent878444 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titleCalcium siganlling in the heart. From contraction to gene expression.
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsCalcium, heart, heart failure, gene expression
dc.subject.courseuuBiology of Disease


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