Calcium siganlling in the heart. From contraction to gene expression.

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Veen, A.A.B. van
dc.contributor.author	Bouwmeester, R.A.M.
dc.date.accessioned	2011-04-18T17:00:45Z
dc.date.available	2011-04-18
dc.date.available	2011-04-18T17:00:45Z
dc.date.issued	2011
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/6885
dc.description.abstract	The human heart contracts approximately 75 times per minute under resting conditions. These contractions are mediated by fluctuations in cytosolic Ca2+ concentration. In heart failure the cardiomyocytes are not able to handle these Ca2+ signals properly. As a consequence the heart starts to remodel, a process initiated by altered gene transcription. The regulation of these processes is mediated by one and the same signalling ion, i.e. Ca2+. This review will discuss Ca2+ handling mechanisms ranging from cytosolic Ca2+ homeostasis and the regulation of gene expression to their role in heart failure.
dc.description.sponsorship	Utrecht University
dc.format.extent	878444 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en
dc.title	Calcium siganlling in the heart. From contraction to gene expression.
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	Calcium, heart, heart failure, gene expression
dc.subject.courseuu	Biology of Disease