dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Rheenen, J. van | |
dc.contributor.author | Masselink, W.H.B. | |
dc.date.accessioned | 2011-03-28T17:01:47Z | |
dc.date.available | 2011-03-28 | |
dc.date.available | 2011-03-28T17:01:47Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/6813 | |
dc.description.abstract | The ligand CXCR4 and its receptor SDF1 have been associated on several occacions
with the formation of the limb musculature, specifically SDF1/CXCR4
signaling has been implicated to be associated with migration of the limb muscle
precursor cells. In this thesis I will provide an overview of SDF1/CXCR4
signaling and how this pleiotropic signaling cascade could be involved in the
regulation of the core mechanism regulation migration of limb muscle precursor
cells. These interactions point to a top role of FGFs, SF/HGF and Shh in
the limb bud mesenchyme to control both CXCR4 and SDF1 signaling, either
directly (SDF1, CXCR4) or potentially through other factors such as NF-kB.
Downstream of CXCR4 three potentially interesting mechanism can be distinguished.
First JAK/STAT signaling which is also controlled by EphA4 which is
also expressed in the migrating muscle precursors. Second a positive feedback
loop of CXCR4 involving SHIP2, PI-3K and NF-kB. Third we can distinguish
a potential mechanism by which CXCR4 regulates c-met by signaling through
MAPK and Gab1. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 231641 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | |
dc.title | CXCR4 and SDF1 are part of the core regulatory mechanism regulating migration of muscle precursor cells to the developing limb | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | CXCR4, SDF1, vertebrate, muscle development, limb bud, c-met | |
dc.subject.courseuu | Cancer Genomics and Developmental Biology | |