Oncogene collaboration revisited from a historical perspective

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Rene Bernards, Prof Dr Rene Bernards
dc.contributor.author	Cadapa Prahallad, A.
dc.date.accessioned	2010-09-03T17:01:05Z
dc.date.available	2010-09-03
dc.date.available	2010-09-03T17:01:05Z
dc.date.issued	2010
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/5584
dc.description.abstract	In 1983, a seminal work from the lab of Robert Weinberg entitled “Tumorigenic conversion of embryo fibroblast requires two cooperating oncogenes” opened up a new dimension for cancer research. It discusses the mechanism of how one could convert a primary cell into a malignant one by introducing defined genetic elements (oncogenes RAS and myc), which cooperate to induce cancer. I will describe in this thesis that this model of oncogene collaboration had its roots in earlier work on how the viral oncogenes of DNA and RNA tumor viruses cooperate to induce cancer. Nevertheless, it was a landmark discovery that cellular oncogenes also act in synergy to cause malignant transformation.
dc.description.sponsorship	Utrecht University
dc.language.iso	en
dc.title	Oncogene collaboration revisited from a historical perspective
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	DNA , RNA tumor viruses, RAS, Myc , primary cells , immortalization
dc.subject.courseuu	Cancer Genomics and Developmental Biology