dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | van Haren, N.E.M. | |
dc.contributor.advisor | Bootsman, F. | |
dc.contributor.advisor | Böcker, K.B.E. | |
dc.contributor.author | Oudman, F.A. | |
dc.date.accessioned | 2010-07-30T17:02:19Z | |
dc.date.available | 2010-07-30 | |
dc.date.available | 2010-07-30T17:02:19Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/5064 | |
dc.description.abstract | Pathological impulsivity is one of the most often reported characteristics of bipolar and
schizophrenic patients. Besides impulsivity, symptoms of both diseases are seen in
schizoaffective disorder and there are many genetic, structural brain and neurocognitive
communalities between the two disorders. Therefore, we conducted a PUBMED search
on studies investigating impulsivity by means of functional neuroimaging (fMRI and
PET) during the Stroop and Continuous Performance Paradigm in schizophrenia and
bipolar disorder. A total of 48 articles matching our criteria were identified and used as
the basis for this review. Bipolar patients far less often showed decreased performance (1
out of 16 articles) relative to schizophrenia patients (18 out of 32 articles) when
compared to controls. Moreover, in schizophrenia, accuracy deficits were found to be
both the result of inattention as well as impulsivity related problems. We argue that
schizophrenia patients are more hampered on task performance and related brain
activation than bipolar patients, since the right middle frontal cortex, right ventrolateral
prefrontal cortex and anterior cingulate cortex are reliably found to be hypoactivated in
schizophrenia while hypoactivation is often restricted to the right ventrolateral prefrontal
cortex in bipolar disorder. However, we suggest that the results of this study merely
reflect a general finding on executive functioning in bipolar disorder and schizophrenia,
which is supported by correspondence to recent literature on executive functioning and
morphological alterations in schizophrenia and bipolar disorder. Besides, this review
elaborates on methodological problems such as IQ differences between groups,
medication intake and lack of statistical power. We argue these characteristics to be
crucial confounders and recommend the application of novel paradigms to further
investigate impulsivity in bipolar disorder and schizophrenia. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 591450 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.title | Impulsivity in bipolar disorder and schizophrenia:
a review on functional imaging studies | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | schizophrenia, bipolar disorder, manic depression, fMRI, functional Magnetic Resonance Imaging, PET, Positron Emission Tomography, Stroop, Go no-go, Continuous Performance Task, response inhibition, executive functioning, Euthemia, confounders, medication | |
dc.subject.courseuu | Neuroscience and Cognition | |