| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Akhmanova, A.S. | |
| dc.contributor.author | Ducarne, Zoé | |
| dc.date.accessioned | 2025-10-01T23:02:53Z | |
| dc.date.available | 2025-10-01T23:02:53Z | |
| dc.date.issued | 2025 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/50472 | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | Using live-cell microscopy and EB mutant rescue experiments in HeLa cells, this thesis defines erratic MT growth behavior, characterized by rapid back-and-forth displacement. We developped a novel analysis pipeline to quantify this behavior and reveal that SxIP +TIPs, not CAP-Gly +TIPs, are key for stable MT growth. EB1-EB3 heterodimers fully rescue erratic behavior, while a rapalog-inducible system proves ineffective. | |
| dc.title | The Effects of End-Binding Proteins on Microtubule Dynamics: How EBs Prevent Microtubule Displacement | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.courseuu | Molecular and Cellular Life Sciences | |
| dc.thesis.id | 40675 | |
