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Using adult stem cells-derived organoids to model endometrial homeostasis and disease

dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorExterne beoordelaar - External assesor,
dc.contributor.authorSchürmann, Paul
dc.date.accessioned2025-09-03T23:02:25Z
dc.date.available2025-09-03T23:02:25Z
dc.date.issued2025
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/50314
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectWe used the recently developed CRISPR-Cas9 base-editing to introduce hotspot mutations in endometrial organoids and establish a model of early tumorigenesis. We sequentially introduced PTEN, PIK3CA and TP53 mutations, three of the most frequently mutated genes in endometrial cancer and established a drug screening platform to investigate the sensitivity of these models to different modulators of the PI3K pathway.
dc.titleUsing adult stem cells-derived organoids to model endometrial homeostasis and disease
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.courseuuDrug Innovation
dc.thesis.id53590


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