The effect of the O-antigen of LPS to Host Defense Peptides

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Veldhuizen, Edwin
dc.contributor.author	Pannekoek, Arianne
dc.date.accessioned	2022-02-18T00:00:28Z
dc.date.available	2022-02-18T00:00:28Z
dc.date.issued	2022
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/502
dc.description.abstract	Recent theories suggested that activity of host defense peptides is enhanced by the presence of an O-antigen. In this study, HDP activity was correlated to binding affinity of HDPs to LPS with and without an O-antigen. The results showed no significant differences between with bacteria or LPS with an O-antigen and bacteria or LPS without an O-antigen. This suggests there is no important role for the O-antigen in the antimicrobial function of HDPs.
dc.description.sponsorship	Utrecht University
dc.language.iso	EN
dc.subject	Lipopolysaccharides seem to play an important role in the antimicrobial activity of Host Defense Peptides. Not all Gram Negative bacteria have an O-antigen in their lipopolysaccharides. This study investigates whether there is a difference between absence or presence of the O-antigen.
dc.title	The effect of the O-antigen of LPS to Host Defense Peptides
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	Host Defense Peptides; HDP; Antimicrobial peptides; AMP; Lipopolysaccharide; LPS; O-antigen;
dc.subject.courseuu	Geneeskunde van gezelschapsdieren
dc.thesis.id	2349