| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Fuchs, Sabine | |
| dc.contributor.author | Noothoven van Goor, Johannes | |
| dc.date.accessioned | 2025-08-01T00:01:44Z | |
| dc.date.available | 2025-08-01T00:01:44Z | |
| dc.date.issued | 2025 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/49484 | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | Mitochondrial disorders are a subgroup of heritable genetic diseases, induced by mutations in the nuclear or mitochondrial genome. These disorders can lead to severe symptoms, such as muscle weakness and neurological issues, drastically undermining the quality of life for patients. Gene editing tools like CRISPR-Cas show great promise in correcting DNA defects. However, due to the need of gRNA they are not capable of efficiently crossing the mitochondrial membrane. DdCBE, developed by Mok et al, | |
| dc.title | Advancing Mitochondrial Disorder Therapy: Virus-Like Particle Delivery of DdCBE Achieves Mitochondrial Genome Editing | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.courseuu | Science and Business Management | |
| dc.thesis.id | 40663 | |
