| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor | Erianna Alvarado-Melendez, Tom Wennekes | |
| dc.contributor.advisor | Wennekes, Tom | |
| dc.contributor.author | Elst, Sebastiaan van | |
| dc.date.accessioned | 2024-11-23T00:01:04Z | |
| dc.date.available | 2024-11-23T00:01:04Z | |
| dc.date.issued | 2024 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/48171 | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | In this work, the in silico design of photo regulatory probes for the T. cruzi trans-sialidase and the progress on the synthesis thereof is reported. Photoswitchable inhibitors have become of interest to medicinal chemists due to the bio-orthogonal properties of visible light. Docking studies and (TD-)DFT calculations were performed to predict probe affinities and their photophysical properties. For the synthesis of the candidates, a modular approach was designed in which the glycan derivatives | |
| dc.title | In Silico Design & Chemical Synthesis of Diazenyl Photoswitches for the Regulation of Trypanosoma Cruzi trans-Sialidase Activity | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.courseuu | Nanomaterials Science | |
| dc.thesis.id | 26808 | |
