Development of an in vitro Bone Sarcoma Model for Testing B7H3-Specific, Interleukin-18-Enhanced CAR T Cells
| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Rossig, Claudia | |
| dc.contributor.author | Molkenbur, Ronja | |
| dc.date.accessioned | 2024-11-21T00:01:49Z | |
| dc.date.available | 2024-11-21T00:01:49Z | |
| dc.date.issued | 2024 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/48167 | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | In this thesis the establishment of an in vitro bone sarcoma model was described to test B7H3-targeting, IL-18-enhanced CAR T cells. By gene editing using CRISPR-Cas9 and lentiviral transduction tumor cells with different target antigen densities were generated and B7H3 expression was quantified by qPCR and flow cytometry. | |
| dc.title | Development of an in vitro Bone Sarcoma Model for Testing B7H3-Specific, Interleukin-18-Enhanced CAR T Cells | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.courseuu | Bio Inspired Innovation | |
| dc.thesis.id | 41181 |