| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Boer, Rob de | |
| dc.contributor.author | Meer, Leroy van der | |
| dc.date.accessioned | 2024-09-11T23:01:44Z | |
| dc.date.available | 2024-09-11T23:01:44Z | |
| dc.date.issued | 2024 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/47714 | |
| dc.description.abstract | Recent efforts in developing bacteriophage-based treatments for B. glumae infection have identified a Jumbo phage FLC4-4c as a potential candidate. This Jumbo phage has a wide host range and is capable of infecting both Burkholderia plantarii and Burkholderia gladioli. However, while performing plaque assays on B. plantarii bacterial lawns, the phage suddenly loses its ability to infect. In this project, we validate the experimentally found abrupt disappearance in plaque formation. Dispite the implementation of alternative density-dependent resistance mechanisms in the bacteria, we were unable to recreate the abrupt disappearance as observed previously | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | While researching bacteriophage host interactions on plates, an interesting phenomenon was observed. while serially diluting phage pressure on specific bacteria, an abrupt dissapearance of successful infection is observed. In this project the population dynamics for both the bacteria and phages are modeled to better understand what could cause the observed effect. | |
| dc.title | A modelling approach to uncovering hostspecific interactions by jumbo phage
FLC4-4c | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.keywords | Jumbo phage, Burkholderia plantarii, Ralstonia pseudosolanacearum, Cellular automaton, Plaque assay | |
| dc.subject.courseuu | Environmental Biology | |
| dc.thesis.id | 39136 | |
