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External validation of six models for model informed precision dosing of patients treated with voriconazole

dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorEgberts, A.C.G.
dc.contributor.authorBrouwer, Michiel
dc.date.accessioned2024-08-07T23:02:16Z
dc.date.available2024-08-07T23:02:16Z
dc.date.issued2024
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/47123
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectVoriconazole dosing is complicated by multiple factors that can lead to relevant changes in voriconazole's pharmacokinetics (PK). Data from several studies suggest that model-informed precision dosing (MIPD) is a tool to predict voriconazole plasma concentrations and to establish the right dose to reach the therapeutic range. (1,2) This study aimed to retrospectively validate existing pharmacokinetic population models of voriconazole to assess their suitability in MIPD.
dc.titleExternal validation of six models for model informed precision dosing of patients treated with voriconazole
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.courseuuFarmacie
dc.thesis.id36192


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