From the gut to the AD brain: Identifying bioavailable therapeutic (poly)phenols and their metabolites for the treatment of Alzheimer’s Disease

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Caiazzo, Massimiliano
dc.contributor.author	Bahtiri, Sibel
dc.date.accessioned	2024-06-05T23:02:05Z
dc.date.available	2024-06-05T23:02:05Z
dc.date.issued	2024
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/46483
dc.description.sponsorship	Utrecht University
dc.language.iso	EN
dc.subject	Polyphenols are molecules derived from plants that can interfere with multiple disease mechanisms in AD. The remaining challenges for polyphenols as therapeutic candidates mainly relate to their bioavailability, as they are subject to metabolizations by gut microflora in order to be absorbed and exert their neuroprotective effect. Therefore, we propose to investigate bioavailable polyphenol metabolites and their bioactivity using several in vitro strategies.
dc.title	From the gut to the AD brain: Identifying bioavailable therapeutic (poly)phenols and their metabolites for the treatment of Alzheimer’s Disease
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.courseuu	Drug Innovation
dc.thesis.id	17318